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Appendix A: Glossary

General Terms

DNA Synthesis

The process of creating DNA molecules. All living cells replicate DNA before mitosis or meiosis. DNA can also by synthesized artificially through various methods, including polymerase chain reactions (PCR).

Drinking Water Equivalency Level (DWEL)

Defines the concentration of a pollutant believed to cause no adverse, non-cancer health effects over a lifetime, assuming that all of the exposure to a contaminant comes from drinking water.

Ecotoxic

Substances that are poisonous to the ecosystem.

Efferent Pathway

Method of transmitting information from the central nervous system to muscles and organs.

Electromagnetic Radiation

Beam of energy composed at photons, which travel at the speed of light, 300,000 km/hr.

Elemental Carbon

Light-absorbing material in particles found in the atmosphere and usually produced from the combustion of gaseous and liquid hydrocarbons with restricted air supply. Often carries other harmful chemicals. Also called black carbon.

Emphysema

A pathological condition of the lungs marked by an abnormal increase in the size of the air spaces, resulting in labored breathing and an increased susceptibility to infection. It can be caused by irreversible expansion of the alveoli or by the destruction of alveolar walls.

Endocrine Disrupting Chemicals (EDCs)

Substances which can improperly regulate and emulate the body's hormones, disrupting growth and development, energy levels and reproductive health.

Endocrine Gland

Any of the body's glands that produce hormonal secretions that pass directly into the bloodstream, such as the thyroid gland.

Endothelial Injury Hypothesis

An alternative theory to the lipid hypothesis, positing that oxidized, relatively small, dense low-density-lipoproteins (LDL) are the primary cause of atherosclerotic plaque and CVD. This challenges the causal link between saturated fat intake and risk of heart disease.

Environmental Product Declaration (EPD)

Quantified environmental data for a product with pre-set categories of parameters based on the International Organization of Standards (ISO) 14040 series of standards, but not excluding additional environmental information.

Environmental Relative Moldiness Index (ERMI)

Rating of mold level based on sample of dust from within building. Takes degree of activity and toxicity of mold species.

Enzymes

Protein molecules made by the body that act as catalysts to modulate a vast array of biochemical reactions.

Epidemiological Research

Study of the distribution and correlation of health-related states or events (including disease) based on populations exposed to different environmental conditions.

Epidermis

The outermost layer of the skin.

Epigenetics

The study of how genes produce their effect on the observable properties of an organism, including environmental triggers.

Epinephrine and Norepinephrine

These hormones are triggered during times of extreme acute stress, in high enough doses imbue tremendous, but momentary strength. They are released in one two primary scenarios. The first is psychological. In a stressful situation, they are released in order to deal with the perceived threat at hand. The second is physiologically. Hormone release is triggered during periods of intense physical exertion.

Erythema

Reddening of the skin caused by an excess in blood in the skin capillaries.

Evaporation

The vaporization of perspiration from a body. This is commonly used a mechanism for thermal regulation.

Evidence-based Technology

Best methods and technologies to achieve a specific result, determined by evidence from current and well-conducted research.

Extra-spectral Colors

Saturated color which cannot be produced with a prism and white light or a single-wavelength laser.

Fel d 1

Protein in cat saliva that can produce allergic or asthmatic responses in humans.

Fenestration

An opening in a surface (as a wall or membrane).

Fetotoxicity

Resulting in toxicity of the fetus.

Fibrosis

A condition marked by an increase of fibrous tissue between tissue or part of an organ, whether in a reparative or reactive process.

Flow Cytometry

A laser based technique employed in cell counting, sorting and protein engineering.

Focus Zone

A physical area within a building that encourages concentration and attentiveness to a task among occupants though its strategic layout and design.

Food and Drug Administration (FDA)

The Food and Drug Administration (FDA) is an agency within the U.S. Department of Health and Human Services. The core functions of the agency are: Medical Products and Tobacco, Foods and Veterinary Medicine, Global Regulatory Operations and Policy and Operations.

Food Intolerances

Food sensitivity usually caused by difficulty digesting a particular food that does not involve an immune system response or the release of histamine.

Free Address

Ability for occupants to be able to choose their own workspace within the office or workplace.

Free Radical Scavenger
Full Time Employee

A full time employee is one who works at least the minimum amount of hours as definied by his or her employer. This is generally defined as 8 hours a day, 5 days a week.

Fungi

Any of a group of unicellular, multicellular or syncytial spore-producing organisms feeding on organic materials.

Furans

One of a group of colorless, volatile, heterocyclic organic compounds

Gamma Radiation

Ionizing electromagnetic radiation of wavelengths less than 0.001 nm, often produced as a result of radiactive decay.

Gastric Juices

A low pH digestive fluid produced in the stomach.

Gastroesophageal Reflux Disease (GERD)

A persistent digestive disorder that occurs when stomach acid or bile flows back (refluxes) into the food pipe or esophagus.

Genotoxic

A chemical or other agent that damages genetic material or reproduction, resulting in mutations or cancer.

Giardia

Protozoa that can live in the small intestine of humans and lead to severe digestive problems.

Glazing

Glasswork, which must be carefully designed in order to avoid excessive glare and heat gain.

Glioma

Cancer which arises in the glial cells of the brain and spinal column.

Glucocorticoids

Steroids which contribute to control of the immune system.

Gluten Intolerance

A spectrum of disorders, including celiac disease, wheat allergy and idiopathic gluten sensitivity, characterized by bloating, abdominal discomfort, diarrhea, bone or joint pain as a result of eating gluten.

Glycogen

Glycogen is the body's storage form of glucose. The glycogen that is stored in muscles is for on-site use only, whereas the glycogen that is stored in the liver serves to maintain glucose homeostasis in the bloodstream. Glycogen stored in muscle is typically reserved for times of "emergency", and can be quickly metabolized on the spot.

Glycolysis

Process of metabolism which occurs during strenuous exercise in which cells produce ATP anaerobically and generate lactic acid as a byproduct.

Growth Hormone

A hormone that stimulates growth, cell reproduction and regeneration. It has an anabolic effect on the body, playing a critical role in childhood development and organ and muscle growth. It is boosted in the body during fasting, restful sleep and exercise.

Gypsum

Gypsum is a soft sulfate mineral composed of calcium disulfate and commonly used in drywall and plasters.

Half-life

The time required for something to fall to half its initial value.

Halogenated Flame Retardants (HFR)

Chemical compounds containing chlorine or bromine bonded to carbon, used in compounds to create products to meet flammability requirements.

Health Product Declaration (HPD)

A standard format for reporting product content and associated health information for building products and materials.

Healthy Building Network

An organization that publishes and researches information on the sustainability of building materials and advocates environmentally friendly building materials and building policies.

Heart Disease

A class of disease that affects the heart, arteries, capillaries or veins.

Heat Recovery Ventilation (HRV)

Ventilation system that employs an air to air heat exchanger for the transfer of moisture and heat from outbound air to inbound circulated air.

Heating, Ventilating, and Air Conditioning System (HVAC)

Equipment, distribution systems and terminals that provide the processes of heating, ventilating or air conditioning.

Hemoglobin

Iron-containing protein which red blood cells their characteristic color and functions primarily in the transport of oxygen from the lungs to the tissues of the body.

Hexavalent Chromium

A positive oxidated state of chromium, used for production of stainless steel, textile dyes, wood preservation, leather tanning and as anti-corrosion and conversion coatings.

High Efficiency Particulate Air (HEPA) Filter

Filter which removes 99.97% of all particles greater than 0.3 micrometers and satisfies standards of efficiency set by the Institute of Environmental Sciences and Technology.

Highly-processed Oils

Oils that are highly processed to remove impurities and therefore to withstand cooking heat. This usually leaves the oils prone to oxidation.

High-touch Surfaces

Surfaces that are frequently touched by building users and occupants such as door knobs, hand rails and tables. See Table A1.

Homeostasis

A state of having regulated responses to environmental conditions to retain stability.

Hormone Disruptors

A chemical that interferes with the signalling of the endocrine system in mammals and that can lead to developmental disorders, birth defects and cancer.

Humidifier Fever

Flu-like illness marked by fever, headache, chills and malaise but without prominent pulmonary symptoms. It is a disease of uncertain origin, with onset occurring a few hours after exposure usually to amoebae, bacteria and fungi found in humidifier reservoirs, air conditioners and aquaria.

Hydrocarbon

A compound comprised of elements hydrogen and carbon, such as components of petroleum and natural gas.

Hydrogen Sulfide

A colorless, flammable, water-soluble, poisonous gas, having the odor of rotten eggs and used in the manufacture of chemicals, in metallurgy and as a reagent.

Hygrothermal

A term used to connect heat and moisture flows and their combined effect on building envelope (enclosure) performance.

Hyperpallatable

Food that is designed, engineered or marketed to be as desirable as possible. Often characterized by the presence of excessive salt, sweeteners and oils, these foods can overcome feelings of satiety to induce overeating..

Hypersensitivity

Oversensitivity or an exaggerated immune response to what is perceived as a foreign substance.

Hypersensitivity Pneumonitis

An inflammation of the alveoli within the lung caused by hypersensitivity to inhaled organic dusts. Symptoms usually include fever, chills, fatigue, breathlessness, cough and chest tightness.

Hypertension

Or high blood pressure is a chronic medical condition in which the heart has to work harder than normal to circulate blood, and is a risk factor for stroke, heart attack, kidney disease and other conditions.

Hypothalamic-pituitary-adrenal (HPA) Axis

Part of the hypothalamus which regulates digestion, mood and other aspects through hormone feedback loops.

Hypothalamic-pituitary-gonadal (HPG) axis

Part of the hypothalamus which regulates sex hormone release.

Hypothalamus

Part of the brain that links the endocrine system with the nervous system through the pituitary gland.

Hypothyroidism

A condition in which the thyroid gland does not produce enough of certain hormones, which over time can lead to several health problems including overweight and obesity, joint pain and heart disease.

Hypoxia

Hypoxia is an abnormal condition of the body in which oxygen intake or use is inadequate causing a deficiency in the amount of oxygen reaching body tissues.

Igneous Rock

Rock formed by the solidification of molten magma.

Immune Modulation

Regulation of the immune system and response by agents that activate or suppress its function.

Immune Response

The reaction of the cells and fluids of the body to the presence of a substance that is perceived as a potential threat.

Immune System

The integrated body system of organs, tissues, cells and cell products such as antibodies that differentiates self from non-self and neutralizes potentially harmful organisms or substances.

Immunoassays

Test used to detect the presence or quantity of a substance based on its capacity to act as an antigen or antibody.

Immuno-compromised

An inability to develop a normal immune response, usually as a result of disease, malnutrition or medical therapy that affects the immune system.

Immunosuppressive

Any compound or substance that may impair proper immune functioning.

Incus

Anvil shaped bone in the middle ear located between the malleus and stapes. The incus transmits vibrations from the malleus to the stapes.

Infiltration

Unintentional or incidental introduction of outside air into a building, typically through cracks in the building envelope and through use of doors for passage.

Inflammation

Localized protective reaction of tissue to irritation, injury or infection, characterized by pain, redness, swelling and sometimes loss of function.

Inflammatory Bowel Disease (IBD)

A group of autoimmune diseases of the colon and small intestine, including chron's disease and ulcerative colitis.

Influenza

An acute contagious viral infection characterized by inflammation of the respiratory tract and by fever, chills, muscular pain and prostration.

Infrared Radiation

Non-ionizing electromagnetic radiation having wavelengths between 700 and 1,000,000 nm.

Infrasound

Sound waves with frequencies less than 20 Hz. Too low for the human ear to hear.

Insecticides

Chemicals applied to crops or structures to reduce the harmful effects of insect pests.

Insulin

Hormone which helps regulate the metabolism of carbohydrates and fat and signals the absorption of glucose from the blood.

Insulin Sensitivity

A condition in which cells become resistant and fail to respond to insulin, which causes elevated levels of cluose and fatty acids in the blood stream.

Interesterified Fat

A type of oil in which fatty acids held in triglycerides have been reconfigured. These fats were designed to replace trans-fats in commercial baked goods and processed foods. There is little known about their health effects.

Intermittent Fasting

Any eating pattern in which the timing of calorie-consumption is restricted on a daily or weekly basis. A common intermittent fasting pattern is characterized by an 8-hour eating window and a 16-hour fasting period.

Intervertabal Disc

Intervertebral discs (IVD) are the cartilaginous joints that lie between adjacent vertebra in the spine. Each disc allows slight movement of the vertebrae and acts as a ligament to hold the vertebrae together.

Intracellular

The space inside of a cell.

Intrinsically Photoreceptive Retinal Ganglion Cells (ipRGCs)

Relay environmental light levels to the suprachiasmatic nucleus through the retinohypothalamic tract. Most sensitive to blue light.

Ionization

The process by which an atom or a molecule looses or gains an electron thereby acquiring a negative or positive charge.

Irritable Bowel Syndrome (IBS)

Irritation of the colon affecting the large intestine or colon causing cramping, abdominal pain, bloating, diarrhea and constipation. Usually controlled through dietary and stress management.

Ketones

Nourishing, neuroprotective and immune-supporting compounds that are converted from dietary medium-chained fatty acids in the liver. Ketone-producing diets increase HDL, improve weight loss and kill or inhibit the growth of parasites, viruses and fungi. Ketogenic diets can protect and heal neurons, improving spinal injury recovery time, reducing the severity of and in some cases reversing epilepsy, alzheimers, MS and parkinson's disease, autism and schizophrenia.

Krebs Cycle

Process of metabolism in which cells produce ATP aerobically within the mitochondria and is the primary energy process of cells.