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Appendix A: Glossary

General Terms

Trace element

A chemical element required only in small or minute amounts by living organisms for normal growth and function.

Respiration

The act of breathing or the heating of incoming air to the core body temperature (CBT) then breathing out.

Healthy Building Network

An organization that publishes and researches information on the sustainability of building materials and advocates environmentally friendly building materials and building policies.

Heart Disease

A class of disease that affects the heart, arteries, capillaries or veins.

Heat Recovery Ventilation (HRV)

Ventilation system that employs an air to air heat exchanger for the transfer of moisture and heat from outbound air to inbound circulated air.

Heating, Ventilating, and Air Conditioning System (HVAC)

Equipment, distribution systems and terminals that provide the processes of heating, ventilating or air conditioning.

Hemoglobin

Iron-containing protein which red blood cells their characteristic color and functions primarily in the transport of oxygen from the lungs to the tissues of the body.

Organochlorine

An organic compound that contains one or more chlorine atoms.

Toxilogical Testing

Conducted to determine safety by ascertaining how damaging a given chemical may be to living or non-living organisms.

Reproductive Toxins

A poison that targets the reproductive system.

Highly-processed Oils

Oils that are highly processed to remove impurities and therefore to withstand cooking heat. This usually leaves the oils prone to oxidation.

High-touch Surfaces

Surfaces that are frequently touched by building users and occupants such as door knobs, hand rails and tables. See Table A1.

Homeostasis

A state of having regulated responses to environmental conditions to retain stability.

Hormone Disruptors

A chemical that interferes with the signalling of the endocrine system in mammals and that can lead to developmental disorders, birth defects and cancer.

Osteomalacia

Softening of the bones. Known as rickets when observed in children.

Humidifier Fever

Flu-like illness marked by fever, headache, chills and malaise but without prominent pulmonary symptoms. It is a disease of uncertain origin, with onset occurring a few hours after exposure usually to amoebae, bacteria and fungi found in humidifier reservoirs, air conditioners and aquaria.

Toxilogical Profile

The overview of a substance surmising health effects via levels of exposure, routes of entry and toxicity testing.

Neurotransmitter

Chemicals that transmit signals from a neuron to a target cell across a synapse. These are an essential component of a functioning nervous system.

Hydrogen Sulfide

A colorless, flammable, water-soluble, poisonous gas, having the odor of rotten eggs and used in the manufacture of chemicals, in metallurgy and as a reagent.

Persistent Bioaccumulative Toxins (PBTS)

A collection of compounds that have high resistance to degradation from abiotic and biotic factors, high mobility in the environment and high toxicity.

Hygrothermal

A term used to connect heat and moisture flows and their combined effect on building envelope (enclosure) performance.

Hyperpallatable

Food that is designed, engineered or marketed to be as desirable as possible. Often characterized by the presence of excessive salt, sweeteners and oils, these foods can overcome feelings of satiety to induce overeating..

Hypersensitivity

Oversensitivity or an exaggerated immune response to what is perceived as a foreign substance.

Hypersensitivity Pneumonitis

An inflammation of the alveoli within the lung caused by hypersensitivity to inhaled organic dusts. Symptoms usually include fever, chills, fatigue, breathlessness, cough and chest tightness.

Toxigenic Molds

Molds that can have a harmful effect when inhaled or ingested.

Sound Wave

Sound waves are pressure variations in a medium (air, water, etc.). The pressure differences create vibrations and are ultimately interpreted as sounds/noises when they reach the ears.

Hypothalamic-pituitary-gonadal (HPG) axis

Part of the hypothalamus which regulates sex hormone release.

Hypothalamus

Part of the brain that links the endocrine system with the nervous system through the pituitary gland.

Hypothyroidism

A condition in which the thyroid gland does not produce enough of certain hormones, which over time can lead to several health problems including overweight and obesity, joint pain and heart disease.

Hypoxia

Hypoxia is an abnormal condition of the body in which oxygen intake or use is inadequate causing a deficiency in the amount of oxygen reaching body tissues.

Igneous Rock

Rock formed by the solidification of molten magma.

Motor Neurons

Nerve cells which transmit signals from the CNS to muscles and glands.

Toluene Diisocyanate

Clear, colorless to pale-yellow liquid with a pungent odor. Used primarily to manufacture flexible polyurethane foams for use in furniture, bedding and automotive and airline seats.

Regularly Occupied Space

An areas where workers or other building occupants perform focused activities inside a building for an average of one hour a day or more.

Immune System

The integrated body system of organs, tissues, cells and cell products such as antibodies that differentiates self from non-self and neutralizes potentially harmful organisms or substances.

Immunoassays

Test used to detect the presence or quantity of a substance based on its capacity to act as an antigen or antibody.

Immuno-compromised

An inability to develop a normal immune response, usually as a result of disease, malnutrition or medical therapy that affects the immune system.

Immunosuppressive

Any compound or substance that may impair proper immune functioning.

Myocardial Infarction

An acute episode of heart disease marked by the damage of heart muscle due to insufficient blood supply to the heart muscle, also called a heart attack.

Incus

Anvil shaped bone in the middle ear located between the malleus and stapes. The incus transmits vibrations from the malleus to the stapes.

Tissues

A group of cells that perform a common and specified function. At an organizational level, tissues are between cells and organs.

Reference Dose (RfD)

Daily ingestion level of at substance believed to have no harmful effect to most people. Typically 100 to 1000 times less the No Observed Adverse Effects Level, and sometimes 10 times larger than the Population Adjusted Dose.

Inflammatory Bowel Disease (IBD)

A group of autoimmune diseases of the colon and small intestine, including chron's disease and ulcerative colitis.

Influenza

An acute contagious viral infection characterized by inflammation of the respiratory tract and by fever, chills, muscular pain and prostration.

Infrared Radiation

Non-ionizing electromagnetic radiation having wavelengths between 700 and 1,000,000 nm.

Infrasound

Sound waves with frequencies less than 20 Hz. Too low for the human ear to hear.

Organotin Compounds

Commonly used as anti-fouling agents, an organic compound with one or more tin atoms in its molecules.

Insecticides

Chemicals applied to crops or structures to reduce the harmful effects of insect pests.

Thyroid Hormone Regulation

Regulation of thyroid hormones responsible for the physical and chemical processes that occur in cells, allow growth and maintain body functions.

Reactive-oxygen Species (ROS)

A natural byproduct of oxygen metabolism, ROS are reactive oxygen intermediates vital to cell signaling and homeostasis. However, an over production of ROS, in times of environmental stress, can cause damage to cells structures.

Interesterified Fat

A type of oil in which fatty acids held in triglycerides have been reconfigured. These fats were designed to replace trans-fats in commercial baked goods and processed foods. There is little known about their health effects.

Intermittent Fasting

Any eating pattern in which the timing of calorie-consumption is restricted on a daily or weekly basis. A common intermittent fasting pattern is characterized by an 8-hour eating window and a 16-hour fasting period.

Intervertabal Disc

Intervertebral discs (IVD) are the cartilaginous joints that lie between adjacent vertebra in the spine. Each disc allows slight movement of the vertebrae and acts as a ligament to hold the vertebrae together.

Intracellular

The space inside of a cell.

Intrinsically Photoreceptive Retinal Ganglion Cells (ipRGCs)

Relay environmental light levels to the suprachiasmatic nucleus through the retinohypothalamic tract. Most sensitive to blue light.

Ionization

The process by which an atom or a molecule looses or gains an electron thereby acquiring a negative or positive charge.

NSF (formerly National Sanitation Foundation)

A standard by which water filters are judged.

Rancidification

The process by which fats, oils and other lipids are decomposed, often resulting in undesirable odors and flavors, reducing nutritional value and introducing harmful oxidative compounds.

Ketones

Nourishing, neuroprotective and immune-supporting compounds that are converted from dietary medium-chained fatty acids in the liver. Ketone-producing diets increase HDL, improve weight loss and kill or inhibit the growth of parasites, viruses and fungi. Ketogenic diets can protect and heal neurons, improving spinal injury recovery time, reducing the severity of and in some cases reversing epilepsy, alzheimers, MS and parkinson's disease, autism and schizophrenia.

Krebs Cycle

Process of metabolism in which cells produce ATP aerobically within the mitochondria and is the primary energy process of cells.

Lactic Acid

Eventual product of glucose in cells during metabolism which, when its production exceeds a cell's ability to remove it, contributes to the "burning" sensation in exercise.

Pathogen

An infectious biological agent such as bacteria, virus and fungus that is capable of causing disease in its host.

Legionella

Bacterium that thrives in moist conditions found in central heating and air conditioning systems that can cause Legionnaires' disease.

Legionnaires' Disease

A type of pneumonia caused by bacteria. It is initially characterized by symptoms resembling the flu followed by high fever, cough, diarrhea and mental confusion, and may be fatal especially in elderly and individuals with weakened immune systems.

Thorium

A naturally-occurring radioactive metal element found at very low levels in soil.

Stabilizers

Added during material production to impart stabilization against the influence of light and temperature.

Neurodegeneration

An umbrella term for the progressive loss of structure or function of the brain.

Lipid Hypothesis

The theory positing a causal link between higher dietary saturated fat and cholesterol intake with plasma lipoprotein composition and heart disease.

Lipophilic

The affinity or dissolvability of a compound in fat or oil.

Liver

An organ that plays a vital role in a range of important metabolic processes including detoxification, protein synthesis and glycogen storage.

Living Building Challenge

The Living Building Challenge is a certification program for sustainability of the built environment.

Longitudinal Wave

Type of one-dimensional wave made of compressions and rarefactions when traveling through a medium. Characteristics of longitidunal waves are that the distance between the peaks increases and decreases with oscillations.

Thermoregulation

The ability of an organism to maintain its body temperature within certain boundaries. Thermoregulation is one of the key aspects of homeostasis.

Radioactivity

The energy and particles which are released during the decomposition process of atomic nuclei is called radiation.

Lowest Observed Adverse Effect Level (LOAEL)

Smallest level of daily ingestion of at substance shown to have some harmful effect on laboratory test animals. Always larger than the No Observed Adverse Effect Level.

National Ventilation Procedure

ANSI/ASHRAE Standards 62.1 is the recognized standard for ventilation system design and acceptable procedure with regards to establishing an effective ventilation system.

Prismic Colors

Monochromatic color that can be produced by shining white light through a prism.

Nanoparticles

Particles between 1 and 100 nanometers in size.

Mycotoxins

Toxins produced by some species of mold, the toxins are very dangerous to humans and animals.

Mortality

The rate of death due to a disease or other cause.

Period

The duration of one cycle in a wave or wavelength. The reciprocal of frequency

Radiation

Heat transfer resulting from Planck radiation and an imbalance in temperatures between an object and its surroundings. The only mode of heat transfer which can operate in a vacuum.

Malabsorption

Defective or insufficient absorption of nutrients from the small intestine.

Malleus

Mallet shaped bone in the middle ear located between the incus and the tympanic membrane (eardrum).

Malnutrition

A condition that results from insufficient nutrient intake, excess nutrient intake or nutrient intake in the wrong proportions.

Phagocytic Process

Process of engulfing and ingestion of a foreign particle.

Protozoa

Any single-celled eukaryotic (having a nucleus) organism, such as an amoeba.

Morbidity

The rate of incidence of a disease.

Mucosa

The mucus membrane that lines the gastrointestinal tract and other body cavities. Plays an important role in protecting against pathogens.

Neurotoxins

A poison that targets the nervous system, disrupting proper neuron-signalling.

Phosphogypsum

The byproduct of the processing of phosphate ore; mainly in the production of fertilizers.

Mesothelioma

A disease that causes the formation of malignant cancer cells within the lining of the chest, abdomen or heart.

Metabolic

Any biochemical process that occurs within an organism that is necessary to sustain life.

Metabolic Dysregulation

The suite of conditions associated with metabolic syndrome.

Teratogenic

Disrupting the development of the embryo or fetus.

Metabolic Syndrome

A cluster of medical conditions or risk factors that increase the chances of developing cardiovascular disease, diabetes fatty liver disease and several cancers.

The Toxic Substances Control Act (TSCA)

A law passed in the 1970s that regulates the introduction of new or already existing chemicals.

Pulmonary Edema

Abnormal accumulation of fluid in the lungs

Methane

The simplest organic compound - made up of four carbon-hydrogen bonds.

Peripheral Nervous System

Nerve fibers which connect the central nervous system to limbs and organs.