This is a legacy version of the WELL Building Standard. Please check the latest version here.

Appendix A: Glossary

General Terms

Reactive-oxygen Species (ROS)

A natural byproduct of oxygen metabolism, ROS are reactive oxygen intermediates vital to cell signaling and homeostasis. However, an over production of ROS, in times of environmental stress, can cause damage to cells structures.

Rancidification

The process by which fats, oils and other lipids are decomposed, often resulting in undesirable odors and flavors, reducing nutritional value and introducing harmful oxidative compounds.

Hypothalamic-pituitary-gonadal (HPG) axis

Part of the hypothalamus which regulates sex hormone release.

Acute Exposure

Single exposure to an environmental condition (not lasting more than a day). Acute exposures contrast with chronic exposures, which are prolonged and repeated. Single exposures still have effects on health.

Adenosine Triphosphate (ATP)

A high energy bearing molecule found in all living cells, it converts energy stored in food into chemical energy avilable to the cell.

UV Index

Measure of ultraviolet radiation, usually ranging from 1 to 12 during the day on earth. Each unit equals 25 mW/m², weighted to the human erythema response.

Diabetes

A group of diseases that impact the metabolism due to insufficient insulin production (Type 1) and/or high insulin resistance (Type 2), and a leading cause of death. Results in poor blood sugar control, frequent urination, increased thirst, increased hunger and other symptoms.

Krebs Cycle

Process of metabolism in which cells produce ATP aerobically within the mitochondria and is the primary energy process of cells.

National Ambient Air Quality Standards (NAAQS)

The National Ambient Air Quality Standards (NAAQS) are concentration limits set by the EPA for six pollutants known as criteria air pollutants; The NAAQS's primary standards set limits that protect public health, including sensitive populations, while the secondary standard limits are set to protect public welfare, such as visibility impairment and damage crops.

Highly-processed Oils

Oils that are highly processed to remove impurities and therefore to withstand cooking heat. This usually leaves the oils prone to oxidation.

Lipid Hypothesis

The theory positing a causal link between higher dietary saturated fat and cholesterol intake with plasma lipoprotein composition and heart disease.

N-nitrosodimethylamine (NDMA)

Most commonly detected nitrosamine in water supplies. Likely carcinogenic and formed as a result of reactions with chloramine.

Influenza

An acute contagious viral infection characterized by inflammation of the respiratory tract and by fever, chills, muscular pain and prostration.

Conduction

Heat transfer through physical contact with another object.

Substitution Combustibles

Alternative fuels or raw materials used in combustion processes.

Prismic Colors

Monochromatic color that can be produced by shining white light through a prism.

Ventilation Rate

Rate of exchange of outside air, as well as the circulation of air within the building.

Intermittent Fasting

Any eating pattern in which the timing of calorie-consumption is restricted on a daily or weekly basis. A common intermittent fasting pattern is characterized by an 8-hour eating window and a 16-hour fasting period.

Neurodegeneration

An umbrella term for the progressive loss of structure or function of the brain.

Alloy

A metallic material made of a mixture of two or more metallic elements with nonmetallic elements, usually to impart non-corrosive properties.

Alpha Radiation

Ionizing radiation made of a stream of alpha particles (two protons + two neutrons).

Petroleum-based Fertilizers

Petroleum-based synthesized fertilizers were one of the major breakthroughs of the industrial and green revolutions. Today nearly half of all crop yields are directly attributable to synthetic commercial fertilizer. Although these fertilizers can boost yields, over time they lead to lower nutrient content in food, decreased soil biodiversity and are a major source of environmental pollution.

Rod Cells

Photosensitive cells in the eye used to discern peripheral vision in low levels of illumination.

Sound Wave

Sound waves are pressure variations in a medium (air, water, etc.). The pressure differences create vibrations and are ultimately interpreted as sounds/noises when they reach the ears.

Syryl Phenol

A derived version of styrene, which is a colourless, oily liquid, used to manufacture polymers.

Food Intolerances

Food sensitivity usually caused by difficulty digesting a particular food that does not involve an immune system response or the release of histamine.

Trimester

One third (or approximately 13 weeks) of pregnancy.

Animal Testing

Evaluation of toxicity or other effect of a substance or condition through exposure of living animals. A type of in vivo experimentation, as opposed to in vitro.

No Observed Adverse Effect Level (NOAEL)

Daily ingestion level of at substance shown to have no harmful effect on laboratory test animals. Typically 100 to 1000 times larger than the Reference Dose.

Perilymph

The liquid within the inner ear (cochlea).

Curie

Unit of radioactivity corresponding to 37 billion atomic nucleus disintegration per second.

Immunoassays

Test used to detect the presence or quantity of a substance based on its capacity to act as an antigen or antibody.

Core Body Temperature (CBT)

Temperature of an organism far with the body, such as in internal organs.

Food and Drug Administration (FDA)

The Food and Drug Administration (FDA) is an agency within the U.S. Department of Health and Human Services. The core functions of the agency are: Medical Products and Tobacco, Foods and Veterinary Medicine, Global Regulatory Operations and Policy and Operations.

Environmental Product Declaration (EPD)

Quantified environmental data for a product with pre-set categories of parameters based on the International Organization of Standards (ISO) 14040 series of standards, but not excluding additional environmental information.

Apoptosis

Programmed cell death, usually in response to a disabled poisoned cell.

Aquifer

Subterranean source of water. Often tapped for drinking water.

Sensory Neurons

Nerve cells which relay messages from sensory organs to the CNS.

Culturable Mold

Culturable mold can be defined as mold that is alive, and will therefore grow in a culture sample, as opposed to non-culturable mold that is dead or dormant and would go undetected with culture sampling.

Immune System

The integrated body system of organs, tissues, cells and cell products such as antibodies that differentiates self from non-self and neutralizes potentially harmful organisms or substances.

Heart Disease

A class of disease that affects the heart, arteries, capillaries or veins.

Full Time Employee

A full time employee is one who works at least the minimum amount of hours as definied by his or her employer. This is generally defined as 8 hours a day, 5 days a week.

Endothelial Injury Hypothesis

An alternative theory to the lipid hypothesis, positing that oxidized, relatively small, dense low-density-lipoproteins (LDL) are the primary cause of atherosclerotic plaque and CVD. This challenges the causal link between saturated fat intake and risk of heart disease.

Atherosclerosis

A condition in which arterial walls harden and narrow as the result of accumulating plaque within the inner lining of the artery.

Genotoxic

A chemical or other agent that damages genetic material or reproduction, resulting in mutations or cancer.

Particle Radiation

High energy particles made of electrons or protons and neutrons which are produced during radioactive decay.

Mesothelioma

A disease that causes the formation of malignant cancer cells within the lining of the chest, abdomen or heart.

Reproductive Toxins

A poison that targets the reproductive system.

Healthy Building Network

An organization that publishes and researches information on the sustainability of building materials and advocates environmentally friendly building materials and building policies.

High-touch Surfaces

Surfaces that are frequently touched by building users and occupants such as door knobs, hand rails and tables. See Table A1.

Sensitization

Exposure to an allergen that results in the development of hypersensitivity.

Axis

Multiple glands of the endocrine system working together in a specific order.

Axon

Fibrous part of a neuron cell.

Oxidized

Oxidative rancidity occurs during a free radical process where the double bonds of an unsaturated fat are cleaved in the presence of oxygen, relasing volatile aldehydes and ketones.

Safe Drinking Water Act of 1974

Passed by congress in 1974, authorizing the EPA to set national limits on contaminant levels in drinking water making it safe for human consumption. Under this program, EPA regulates public water systems that provide "piped water for human consumption" and serve at least 25 individuals or has 15 service connections.

Giardia

Protozoa that can live in the small intestine of humans and lead to severe digestive problems.

Sleep Hygiene

Personal habits and practices that help maximize sleep quality.

Toxigenic Molds

Molds that can have a harmful effect when inhaled or ingested.

Respiration

The act of breathing or the heating of incoming air to the core body temperature (CBT) then breathing out.

Bioreactive Form

Form or state of a substance that governs whether a contaminant will be assimilated into a cell if it is bioavailable.

Phagocytic Process

Process of engulfing and ingestion of a foreign particle.

Malleus

Mallet shaped bone in the middle ear located between the incus and the tympanic membrane (eardrum).

Mycotoxins

Toxins produced by some species of mold, the toxins are very dangerous to humans and animals.

National Pollutant Discharge Elimination System (NPDES)

Permit program established by the federal government in 1972 to control point-source discharges of wastewater to lakes, streams, wetlands and other surface waters.

Fetotoxicity

Resulting in toxicity of the fetus.

Interesterified Fat

A type of oil in which fatty acids held in triglycerides have been reconfigured. These fats were designed to replace trans-fats in commercial baked goods and processed foods. There is little known about their health effects.

Bone Mineral Density

Parameter of bones indicating the content of minerals such as calcium.

Zircon

A typically brown mineral with crystal or gem-like qualitie. Chief ore of zirconium.

Organ of Corti

The organ of Corti contains the auditory hair cells that respond to the perilymph vibrations and transmit them into electrochemical impulses for the auditory nerve.

Malabsorption

Defective or insufficient absorption of nutrients from the small intestine.

Skeletal Muscle

Muscle tissue that is voluntarily controlled.

Toxilogical Profile

The overview of a substance surmising health effects via levels of exposure, routes of entry and toxicity testing.

Thorium

A naturally-occurring radioactive metal element found at very low levels in soil.

Hydrogen Sulfide

A colorless, flammable, water-soluble, poisonous gas, having the odor of rotten eggs and used in the manufacture of chemicals, in metallurgy and as a reagent.

Developmental Toxins

A subgroup of reproductive toxins that cause malformations of an embryo or fetus. Effects may occur from conception to sexual maturity and include spontaneous abortion, structural or functional defects, low birth weight or effects that may appear later in life.

Watershed

The region draining into a river, river system or other body of water.

Plasticizers

Added during material production to impart varying degrees of elasticity.

Lowest Observed Adverse Effect Level (LOAEL)

Smallest level of daily ingestion of at substance shown to have some harmful effect on laboratory test animals. Always larger than the No Observed Adverse Effect Level.

Styrene-butadiene Rubber (SBR)

The most common type of synthetic rubber, used in tires, footwear, adhesives and sealants.

Thermoregulation

The ability of an organism to maintain its body temperature within certain boundaries. Thermoregulation is one of the key aspects of homeostasis.

Fenestration

An opening in a surface (as a wall or membrane).

Ketones

Nourishing, neuroprotective and immune-supporting compounds that are converted from dietary medium-chained fatty acids in the liver. Ketone-producing diets increase HDL, improve weight loss and kill or inhibit the growth of parasites, viruses and fungi. Ketogenic diets can protect and heal neurons, improving spinal injury recovery time, reducing the severity of and in some cases reversing epilepsy, alzheimers, MS and parkinson's disease, autism and schizophrenia.

Neurocognitive Diseases

Diseases of the brain and nervous system.

Myocardial Infarction

An acute episode of heart disease marked by the damage of heart muscle due to insufficient blood supply to the heart muscle, also called a heart attack.

Non-REM Sleep

Non-rapid eye movement, or non-REM is, collectively, sleep stages 1–3. There are distinct electroencephalographic and other characteristics seen in each stage. Unlike REM sleep, there is usually little or no eye movement during this stage.

Methane

The simplest organic compound - made up of four carbon-hydrogen bonds.

Hypothalamus

Part of the brain that links the endocrine system with the nervous system through the pituitary gland.

Glycolysis

Process of metabolism which occurs during strenuous exercise in which cells produce ATP anaerobically and generate lactic acid as a byproduct.

Fungi

Any of a group of unicellular, multicellular or syncytial spore-producing organisms feeding on organic materials.

Protozoa

Any single-celled eukaryotic (having a nucleus) organism, such as an amoeba.

Clean Air Act

Federal law designed to control air pollution on a national level. Requires the EPA to develop, set standards and enforce regulations that protect the public from airborne contaminants known to be hazardous to human health.

Zeitgebers

Physical stimuli which have an impact on the body's circadian rhythm. Examples include light, temperature and eating or drinking behaviors.

Noncompliant

In terms of air pollution, regions are noncompliant if they fail to achieve standards set by NAAQS.

Ecotoxic

Substances that are poisonous to the ecosystem.

Inflammatory Bowel Disease (IBD)

A group of autoimmune diseases of the colon and small intestine, including chron's disease and ulcerative colitis.

Monomer

A single molecule that may bind chemically with like others to create a ring or chain termed a polymer.

Synthetic Fertilizers

Chemicals added to the soil to encourage plant growth that are not derived from organisms.

Ulcerative Colitis

An inflammatory bowel disease (IBD) that causes long-lasting inflammation in the large intestine and rectum characterized by recurrent episodes of abdominal pain, fever and diarrhea.

Cognitive Impairment

An inclusive term to describe any feature that acts as a barrier to the cognition process, and can be used to describe various types of deficits, whether global, as with mental retardation or specific as when relating to learning disorders.

Wave Amplitude

Measurement of the wave change over a single period of time.