An important and complex relationship exists between our mental and physiological states. Chronic stress adversely impacts the body, from the nervous to the cardiovascular system. Substance addiction is one of the most damaging manifestations of stress, combining the toxicity of the substance itself with the mental distress associated with social stigma and/or attempts to quit. In recent years, refinements in addiction treatment and stress reduction therapies, as well as pharmacological interventions have been successful in helping to mitigate these debilitating conditions.